Advances in our understanding of the metabolism and molecular functions of polyamines
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …

Termination of mRNA translation occurs when a stop codon enters the A site of the
ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a …

Nonsense-mediated mRNA decay (NMD) is arguably the best-studied eukaryotic
messenger RNA (mRNA) surveillance pathway, yet fundamental questions concerning the …

The structure of proline prevents it from adopting an optimal position for rapid protein
synthesis. Poly-proline-tract (PPT) associated ribosomal stalling is resolved by highly …

Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it
is not known whether the metabolic regulation of protein synthesis controls HSPC …

Clostridioides difficile is the most common cause of nosocomial gastrointestinal tract
bacterial infections. We lack fully effective reliable treatments for this pathogen, and there is …

DHPS deficiency syndrome is an ultra-rare neurodevelopmental disorder (NDD) which
results from biallelic mutations in the gene encoding the enzyme deoxyhypusine synthase …

The protein synthesis within eukaryotic cells is a complex process involving various
translation factors. Among these factors, eukaryotic translation initiation factor 5A (eIF5A) …

Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and
differentiation, embryonic development, and innate immune response of macrophages to …

The eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for the viability of
the cells whose proposed function is to prevent the stalling of the ribosomes during …