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Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia
P Lemoine, N Zisapel - Expert opinion on pharmacotherapy, 2012 - Taylor & Francis
Introduction: Insomnia is common among the elderly. The use of hypnotic drugs in elderly
patients is frequently criticized owing to dependency, cognitive impairments, falls and …
patients is frequently criticized owing to dependency, cognitive impairments, falls and …
Efficacy of melatonin and ramelteon for the acute and long‐term management of insomnia disorder in adults: A systematic review and meta‐analysis
J Maruani, E Reynaud, J Chambe… - Journal of Sleep …, 2023 - Wiley Online Library
Melatonin has gained growing interest as a treatment of insomnia, despite contradictory
findings, and a low level of evidence. A systematic review and meta‐analysis was conducted …
findings, and a low level of evidence. A systematic review and meta‐analysis was conducted …
Melatonin effects on sleep quality and outcomes of COVID‐19 patients: an open‐label, randomized, controlled trial
This trial aims to evaluate the effectiveness of adding melatonin to the treatment protocol of
hospitalized coronavirus disease 2019 (COVID‐19) patients. This was an open‐label …
hospitalized coronavirus disease 2019 (COVID‐19) patients. This was an open‐label …
Prolonged‐release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects
P Lemoine, T Nir, M Laudon… - Journal of sleep …, 2007 - Wiley Online Library
Melatonin, secreted nocturnally by the pineal gland, is an endogenous sleep regulator.
Impaired melatonin production and complaints on poor quality of sleep are common among …
Impaired melatonin production and complaints on poor quality of sleep are common among …
Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes
AG Wade, I Ford, G Crawford… - … medical research and …, 2007 - Taylor & Francis
Objective: Melatonin, the hormone produced nocturnally by the pineal gland, serves as a
circadian time cue and sleep-anticipating signal in humans. With age, melatonin production …
circadian time cue and sleep-anticipating signal in humans. With age, melatonin production …
The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia
R Luthringer, M Muzet, N Zisapel… - International clinical …, 2009 - journals.lww.com
Objectives of this study were to investigate the effects of prolonged-release melatonin 2 mg
(PRM) on sleep and subsequent daytime psychomotor performance in patients aged≥ 55 …
(PRM) on sleep and subsequent daytime psychomotor performance in patients aged≥ 55 …
The different faces of insomnia
Objectives: The identification of clinically relevant subtypes of insomnia is important.
Including a comprehensive literature review, this study also introduces new phenotypical …
Including a comprehensive literature review, this study also introduces new phenotypical …
Exploration of basal diurnal salivary cortisol profiles in middle-aged adults: associations with sleep quality and metabolic parameters
The use of saliva samples is a practical and feasible method to explore basal diurnal cortisol
profiles in free-living research. This study explores a number of psychological and …
profiles in free-living research. This study explores a number of psychological and …