[HTML][HTML] On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site
Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …
Drug delivery and release systems for targeted tumor therapy
D Böhme, AG Beck‐Sickinger - Journal of Peptide Science, 2015 - Wiley Online Library
Most toxic agents currently used for chemotherapy show a narrow therapeutic window,
because of their inability to distinguish between healthy and cancer cells. Targeted drug …
because of their inability to distinguish between healthy and cancer cells. Targeted drug …
Liposome-based glioma targeted drug delivery enabled by stable peptide ligands
The treatment of glioma is one of the most challenging tasks in clinic. As an intracranial
tumor, glioma exhibits many distinctive characteristics from other tumors. In particular …
tumor, glioma exhibits many distinctive characteristics from other tumors. In particular …
Peptide-functionalized oxime hydrogels with tunable mechanical properties and gelation behavior
We demonstrate the formation of polyethylene glycol (PEG) based hydrogels via oxime
ligation and the photoinitiated thiol–ene 3D patterning of peptides within the hydrogel matrix …
ligation and the photoinitiated thiol–ene 3D patterning of peptides within the hydrogel matrix …
Recent advances in the biomedical applications of functionalized nanogels
Nanomaterials have been extensively used in several applications in the past few decades
related to biomedicine and healthcare. Among them, nanogels (NGs) have emerged as an …
related to biomedicine and healthcare. Among them, nanogels (NGs) have emerged as an …
Treatment of breast cancer with gonadotropin-releasing hormone analogs
M Huerta-Reyes, G Maya-Núñez… - Frontiers in …, 2019 - frontiersin.org
Although significant progress has been made in the implementation of new breast cancer
treatments over the last three decades, this neoplasm annually continues to show high …
treatments over the last three decades, this neoplasm annually continues to show high …
Gonadotropin-releasing hormone receptors in prostate cancer: molecular aspects and biological functions
F Fontana, M Marzagalli, M Montagnani Marelli… - International journal of …, 2020 - mdpi.com
Pituitary Gonadotropin-Releasing Hormone receptors (GnRH-R) mediate the activity of the
hypothalamic decapeptide GnRH, thus playing a key role in the regulation of the …
hypothalamic decapeptide GnRH, thus playing a key role in the regulation of the …
Cellular internalization and inhibition capacity of new anti-glioma peptide conjugates: physicochemical characterization and evaluation on various monolayer-and 3D …
Most therapeutic agents used for treating brain malignancies face hindered transport
through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these …
through the blood–brain barrier (BBB) and poor tissue penetration. To overcome these …
Recent advances in pH-or/and photo-responsive nanovehicles
The combination of nanotechnology and chemotherapy has resulted in more effective drug
design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor …
design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor …
NGR-peptide− drug conjugates with dual targeting properties
Peptides containing the asparagine-glycine-arginine (NGR) motif are recognized by
CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in …
CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in …