Nicotinamide (NAM) N-methyltransferase (NNMT) was originally identified as the enzyme
responsible for the methylation of NAM, one of the forms of vitamin B3. Methylated NAM is …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

Background The abundance of energy metabolites is intimately interconnected with the
activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of …

Elucidating the mechanism for high metastasis capacity of triple negative breast cancers
(TNBC) is crucial to improve treatment outcomes of TNBC. We have recently reported that …

Nicotinamide N-methyltransferase (NNMT) has been reported to be linked to methylation
reprogramming in cancer cells. However, the role of NNMT in the tumour microenvironment …

Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (NA) to generate 1-
methyl nicotinamide. Since its discovery 70 years ago, the appreciation of the role of NNMT …

Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form
N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases …

Background The metabolic enzyme nicotinamide‐N‐methyltransferase (NNMT) is highly
expressed in various cancer entities, suggesting tumour‐promoting functions. We …

Copy number alterations are crucial for gastric cancer (GC) development. In this study,
Tocopherol alpha transfer protein-like (TTPAL) was identified to be highly amplified in our …

Cancer cells typically exhibit a tightly regulated program of metabolic plasticity and
epigenetic remodeling to meet the demand of uncontrolled cell proliferation. The metabolic …