Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

One important purpose of T cell engineering is to generate tumor-targeted T cells through
the genetic transfer of antigen-specific receptors, which consist of either physiological, MHC …

Intestinal bacteria may modulate the risk of infection and graft-versus-host disease (GVHD)
after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients …

Allogeneic hematopoietic stem cell transplantation (HSCT) has advanced to a common
procedure for treating also older patients with malignancies and immunodeficiency …

Age-related thymic involution is characterized by a progressive regression in thymus size
and a diminishment of thymic structure. A decrease in thymic compartments leads to the …

The promising clinical results obtained with engineered T cells, including chimeric antigen
receptor (CAR) therapy, call for further advancements to facilitate and broaden their …

Common lymphoid progenitors (CLPs) clonally produce both B-and T-cell lineages, but
have little myeloid potential in vivo. However, some studies claim that the upstream …

As the primary site of T‐cell development, the thymus plays a key role in the generation of a
strong yet self‐tolerant adaptive immune response, essential in the face of the potential …

T cell reconstitution following lymphopenia from chemotherapy or stem cell transplant is
often slow and incompetent, contributing to the development of infectious diseases, relapse …

Advances in immune assessment, including the development of T-cell receptor excision
circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and …