Migrastatics—anti-metastatic and anti-invasion drugs: promises and challenges

A Gandalovičová, D Rosel, M Fernandes, P Veselý… - Trends in cancer, 2017 - cell.com
In solid cancers, invasion and metastasis account for more than 90% of mortality. However,
in the current armory of anticancer therapies, a specific category of anti-invasion and …

TGF-β1 signalling in Alzheimer's pathology and cytoskeletal reorganization: a specialized Tau perspective

M Kapoor, S Chinnathambi - Journal of Neuroinflammation, 2023 - Springer
Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its
detachment from microtubules and formation of insoluble intracellular aggregates within the …

Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?

AK Exadaktylos, DJ Buggy, DC Moriarty… - …, 2006 - pmc.ncbi.nlm.nih.gov
Background: Regional anesthesia is known to prevent or attenuate the surgical stress
response; thus, inhibiting surgical stress by paravertebral anesthesia might attenuate …

Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells

SA Hinger, DJ Cha, JL Franklin, JN Higginbotham… - Cell reports, 2018 - cell.com
The regulation and functional roles of secreted coding and long noncoding RNAs
(lncRNAs;> 200 nt) are largely unknown. We previously showed that mutant KRAS …

[HTML][HTML] Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications

H Tan, S Zhang, J Zhang, L Zhu, Y Chen, H Yang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Gastric cancer (GC) is currently the fourth most common malignancy and the third leading
cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) …

[HTML][HTML] Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy

I Riquelme, K Saavedra, JA Espinoza, H Weber… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Gastric cancer (GC) is the third leading cause of cancer mortality worldwide. Although
surgical resection is a potentially curative approach for localized cases of GC, most cases of …

Targeting the cytoskeleton against metastatic dissemination

C Ruggiero, E Lalli - Cancer and Metastasis Reviews, 2021 - Springer
Cancer is a pathology characterized by a loss or a perturbation of a number of typical
features of normal cell behaviour. Indeed, the acquisition of an inappropriate migratory and …

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

CML Beckers, VWM van Hinsbergh… - Thrombosis and …, 2010 - thieme-connect.com
In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42
has been developed from regulatory proteins that regulate specific actin cytoskeletal …

Effect of Propofol on breast Cancer cell, the immune system, and patient outcome

R Li, H Liu, JP Dilger, J Lin - BMC anesthesiology, 2018 - Springer
Breast cancer is the second leading cause of cancer death in women. Surgery is the first line
of treatment for breast cancer. Retrospective clinical studies suggest that the type of …

AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea

L Zhang, Y Fang, F Tan, F Guo, Z Zhang, N Li… - Cellular and Molecular …, 2023 - Springer
Mechanosensitive hair cells (HCs) in the cochlear sensory epithelium are critical for sound
detection and transduction. Mammalian HCs in the cochlea undergo cytogenesis during …