Neisseria meningitidis: Biology, Microbiology, and Epidemiology
NG Rouphael, DS Stephens - Neisseria meningitidis: advanced methods …, 2012 - Springer
Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in
children and young adults worldwide through epidemic or sporadic meningitis and/or …
children and young adults worldwide through epidemic or sporadic meningitis and/or …
Multiscale cancer modeling
Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
Costless metabolic secretions as drivers of interspecies interactions in microbial ecosystems
AR Pacheco, M Moel, D Segrè - Nature communications, 2019 - nature.com
Metabolic exchange mediates interactions among microbes, hel** explain diversity in
microbial communities. As these interactions often involve a fitness cost, it is unclear how …
microbial communities. As these interactions often involve a fitness cost, it is unclear how …
A protocol for generating a high-quality genome-scale metabolic reconstruction
I Thiele, BØ Palsson - Nature protocols, 2010 - nature.com
Network reconstructions are a common denominator in systems biology. Bottom–up
metabolic network reconstructions have been developed over the last 10 years. These …
metabolic network reconstructions have been developed over the last 10 years. These …
The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
R Mahadevan, CH Schilling - Metabolic engineering, 2003 - Elsevier
Genome-scale constraint-based models of several organisms have now been constructed
and are being used for model driven research. A key issue that may arise in the use of such …
and are being used for model driven research. A key issue that may arise in the use of such …
Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
AP Burgard, P Pharkya… - Biotechnology and …, 2003 - Wiley Online Library
The advent of genome‐scale models of metabolism has laid the foundation for the
development of computational procedures for suggesting genetic manipulations that lead to …
development of computational procedures for suggesting genetic manipulations that lead to …
The RAVEN Toolbox and Its Use for Generating a Genome-scale Metabolic Model for Penicillium chrysogenum
We present the RAVEN (R econstruction, A nalysis and V isualization of M e tabolic N
etworks) Toolbox: a software suite that allows for semi-automated reconstruction of genome …
etworks) Toolbox: a software suite that allows for semi-automated reconstruction of genome …
Predicting selective drug targets in cancer through metabolic networks
The interest in studying metabolic alterations in cancer and their potential role as novel
targets for therapy has been rejuvenated in recent years. Here, we report the development of …
targets for therapy has been rejuvenated in recent years. Here, we report the development of …
Multidimensional optimality of microbial metabolism
Although the network topology of metabolism is well known, understanding the principles
that govern the distribution of fluxes through metabolism lags behind. Experimentally, these …
that govern the distribution of fluxes through metabolism lags behind. Experimentally, these …
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that
catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible …
catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible …