State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

Blood and lymphatic vessels form a versatile transport network and provide inductive signals
to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and …

Whole-body imaging techniques play a vital role in exploring the interplay of physiological
systems in maintaining health and driving disease. We introduce wildDISCO, a new …

Abstract Analysis of entire transparent rodent bodies after clearing could provide holistic
biological information in health and disease, but reliable imaging and quantification of …

The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …

Animals constantly receive various sensory stimuli, such as odours, sounds, light and touch,
from the surrounding environment. These sensory inputs are essential for animals to search …

Optical tissue transparency permits scalable cellular and molecular investigation of complex
tissues in 3D. Adult human organs are particularly challenging to render transparent …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …