Kir channel molecular physiology, pharmacology, and therapeutic implications
For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning
W Coyote-Maestas, D Nedrud, Y He, D Schmidt - Elife, 2022 - elifesciences.org
A long-standing goal in protein science and clinical genetics is to develop quantitative
models of sequence, structure, and function relationships to understand how mutations …
models of sequence, structure, and function relationships to understand how mutations …
Advancements in the study of inward rectifying potassium channels on vascular cells
C Li, Y Yang - Channels, 2023 - Taylor & Francis
Inward rectifier potassium channels (Kir channels) exist in a variety of cells and are involved
in maintaining resting membrane potential and signal transduction in most cells, as well as …
in maintaining resting membrane potential and signal transduction in most cells, as well as …
Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
The Na-K-2Cl cotransporter-1 (NKCC1) is an electroneutral Na+-dependent transporter
responsible for simultaneously translocating Na+, K+, and Cl− ions into cells. In human …
responsible for simultaneously translocating Na+, K+, and Cl− ions into cells. In human …
On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer
G protein–gated inwardly rectifying K+(GIRK) channels belong to the inward-rectifier K+(Kir)
family, are abundantly expressed in the heart and the brain, and require that …
family, are abundantly expressed in the heart and the brain, and require that …
A novel small-molecule selective activator of homomeric GIRK4 channels
G protein–sensitive inwardly rectifying potassium (GIRK) channels are important
pharmaceutical targets for neuronal, cardiac, and endocrine diseases. Although a number of …
pharmaceutical targets for neuronal, cardiac, and endocrine diseases. Although a number of …
Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity
HQ Yang, W Martinez-Ortiz, JI Hwang… - Proceedings of the …, 2020 - National Acad Sciences
A physiological role for long-chain acyl-CoA esters to activate ATP-sensitive K+ (KATP)
channels is well established. Circulating palmitate is transported into cells and converted to …
channels is well established. Circulating palmitate is transported into cells and converted to …
Conduction through a narrow inward-rectifier K+ channel pore
H Bernsteiner, EM Zangerl-Plessl, X Chen… - Journal of General …, 2019 - rupress.org
Inwardly rectifying potassium (Kir) channels play a key role in controlling membrane
potentials in excitable and unexcitable cells, thereby regulating a plethora of physiological …
potentials in excitable and unexcitable cells, thereby regulating a plethora of physiological …
Use of a molecular switch probe to activate or inhibit GIRK1 heteromers in silico reveals a novel gating mechanism
G protein-gated inwardly rectifying K+ (GIRK) channels form highly active heterotetramers in
the body, such as in neurons (GIRK1/GIRK2 or GIRK1/2) and heart (GIRK1/GIRK4 or …
the body, such as in neurons (GIRK1/GIRK2 or GIRK1/2) and heart (GIRK1/GIRK4 or …
Ivermectin activates GIRK channels in a PIP2‐dependent, Gβγ‐independent manner and an amino acid residue at the slide helix governs the activation
IS Chen, M Tateyama, Y Fukata… - The Journal of …, 2017 - Wiley Online Library
Key points Ivermectin (IVM) is a widely used antiparasitic drug in humans and pets which
activates glutamate‐gated Cl− channel in parasites. It is known that IVM binds to the …
activates glutamate‐gated Cl− channel in parasites. It is known that IVM binds to the …