γ-Aminobutyric acid (GABA) signalling in plants

SA Ramesh, SD Tyerman, M Gilliham, B Xu - Cellular and Molecular Life …, 2017 - Springer
The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …

The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain

SE Lee, Y Lee, GH Lee - Archives of pharmacal research, 2019 - Springer
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter that is required for
the control of synaptic excitation/inhibition and neural oscillation. GABA is synthesized by …

ScanNet: an interpretable geometric deep learning model for structure-based protein binding site prediction

J Tubiana, D Schneidman-Duhovny, HJ Wolfson - Nature Methods, 2022 - nature.com
Predicting the functional sites of a protein from its structure, such as the binding sites of small
molecules, other proteins or antibodies, sheds light on its function in vivo. Currently, two …

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

BB Williams, AH Van Benschoten, P Cimermancic… - Cell host & …, 2014 - cell.com
Several recent studies describe the influence of the gut microbiota on host brain and
behavior. However, the mechanisms responsible for microbiota-nervous system interactions …

[HTML][HTML] Stiff-person syndrome and GAD antibody-spectrum disorders: GABAergic neuronal excitability, immunopathogenesis and update on antibody therapies

MC Dalakas - Neurotherapeutics, 2022 - Elsevier
Abstract Although antibodies against Glutamic Acid Decarboxylase (GAD) were originally
associated with Stiff Person Syndrome (SPS), they now denote the “GAD antibody-spectrum …

Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons

S Canetta, S Bolkan, N Padilla-Coreano, LJ Song… - Molecular …, 2016 - nature.com
Abnormalities in prefrontal gamma aminobutyric acid (GABA) ergic transmission, particularly
in fast-spiking interneurons that express parvalbumin (PV), are hypothesized to contribute to …

[HTML][HTML] GABAergic signaling as a potential therapeutic target in cancers

Y Yang, L Ren, W Li, Y Zhang, S Zhang, B Ge… - Biomedicine & …, 2023 - Elsevier
GABA is the most common inhibitory neurotransmitter in the vertebrate central nervous
system. Synthesized by glutamic acid decarboxylase, GABA could specifically bind with two …

GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions

P Tsiortou, H Alexopoulos… - Therapeutic advances in …, 2021 - journals.sagepub.com
Antibodies against glutamic acid decarboxylase (GAD), originally linked to stiff person
syndrome (SPS), now denote the “GAD antibody-spectrum disorders”(GAD-SD) that also …

[HTML][HTML] Biosynthesis of Gamma-Aminobutyric Acid (GABA) by Lactiplantibacillus plantarum in Fermented Food Production

M Iorizzo, G Paventi, C Di Martino - Current Issues in Molecular Biology, 2023 - mdpi.com
In recent decades, given the important role of gamma-aminobutyric acid (GABA) in human
health, scientists have paid great attention to the enrichment of this chemical compound in …

Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission

J Zheng, HL Li, N Tian, F Liu, L Wang, Y Yin, L Yue… - Cell stem cell, 2020 - cell.com
Phospho-tau accumulation and adult hippocampal neurogenesis (AHN) impairment both
contribute importantly to the cognitive decline in Alzheimer's disease (AD), but whether and …