DJ-1 in Parkinson's disease: clinical insights and therapeutic perspectives
Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD)
and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions …
and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions …
α-Synuclein and parkinsonism: updates and future perspectives
Mutations in the SNCA gene, which encodes the α-synuclein protein, were the first
discovered genetic causes of familial parkinsonism with Lewy pathology. To date, six …
discovered genetic causes of familial parkinsonism with Lewy pathology. To date, six …
A clinical and molecular genetic study of 50 families with autosomal recessive parkinsonism revealed known and novel gene mutations
In this study, the role of known Parkinson's disease (PD) genes was examined in families
with autosomal recessive (AR) parkinsonism to assist with the differential diagnosis of PD …
with autosomal recessive (AR) parkinsonism to assist with the differential diagnosis of PD …
Genetic variants and animal models in SNCA and Parkinson disease
H Deng, L Yuan - Ageing research reviews, 2014 - Elsevier
Abstract Parkinson disease (PD; MIM 168600) is the second most common progressive
neurodegenerative disorder characterized by a variety of motor and non-motor features. To …
neurodegenerative disorder characterized by a variety of motor and non-motor features. To …
A new iPhone application for measuring active craniocervical range of motion in patients with non-specific neck pain: a reliability and validity study
Abstract Background Context Measurement of cervical spine range of motion (ROM) is often
considered to be an essential component of cervical spine physiotherapy assessment …
considered to be an essential component of cervical spine physiotherapy assessment …
[HTML][HTML] P5B-ATPases in the mammalian polyamine transport system and their role in disease
Polyamines (PAs) are physiologically relevant molecules that are ubiquitous in all
organisms. The vitality of PAs to the healthy functioning of a cell is due to their polycationic …
organisms. The vitality of PAs to the healthy functioning of a cell is due to their polycationic …
Copy number variability in Parkinson's disease: assembling the puzzle through a systems biology approach
Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disorder of aging, was long believed to be a non-genetic sporadic origin …
neurodegenerative disorder of aging, was long believed to be a non-genetic sporadic origin …
Mutations in the ATP13A2 Gene and Parkinsonism: A Preliminary Review
X Yang, Y Xu - BioMed Research International, 2014 - Wiley Online Library
Parkinson's disease (PD) is a major neurodegenerative disorder for which the etiology and
pathogenesis remain as elusive as for Alzheimer′ s disease. PD appears to be caused by …
pathogenesis remain as elusive as for Alzheimer′ s disease. PD appears to be caused by …
Parkinson's disease: available clinical and promising omics tests for diagnostics, disease risk assessment, and pharmacotherapy personalization
Parkinson's disease is the second most frequent neurodegenerative disease, representing a
significant medical and socio-economic problem. Modern medicine still has no answer to the …
significant medical and socio-economic problem. Modern medicine still has no answer to the …
α-Synuclein at the presynaptic axon terminal as a double-edged sword
α-synuclein (α-syn) is a presynaptic, lipid-binding protein strongly associated with the
neuropathology observed in Parkinson's disease (PD), dementia with Lewy bodies (DLB) …
neuropathology observed in Parkinson's disease (PD), dementia with Lewy bodies (DLB) …