Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …

Throughout decades, the intrinsic power of the immune system to fight pathogens has
inspired researchers to develop techniques that enable the prevention or treatment of …

The efficiency of antigen (A g) processing by dendritic cells (DC s) is vital for the strength of
the ensuing T‐cell responses. Previously, we and others have shown that in comparison to …

The interaction of immune cells with drugs and/or with other cell types should be
mechanistically investigated in order to reduce attrition of new drug development. However …

Background Immune system conditions of the patient is a key factor in COVID-19 infection
survival. A growing number of studies have focused on immunological determinants to …

Understanding the cellular and molecular mechanisms that control the ability of the immune
system to mount a protective response against pathogen-derived foreign antigens, but avoid …

Fibroblastic reticular cells (FRCs) form the cellular scaffold of lymph nodes (LNs) and
establish distinct microenvironmental niches to provide key molecules that drive innate and …

Virus spreading in tissues is determined by virus transport, virus multiplication in host cells
and the virus-induced immune response. Cytotoxic T cells remove infected cells with a rate …

One of the greatest challenges in biomedicine is to get a unified view of observations made
from the molecular up to the organism scale. Towards this goal, multiscale models have …

Drug research, therapy development, and other areas of pharmacology and medicine can
benefit from simulations and optimization of mathematical models that contain a …