Pre-eclampsia: pathophysiology and clinical implications

GJ Burton, CW Redman, JM Roberts, A Moffett - Bmj, 2019 - bmj.com
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical
presentation is highly variable but hypertension and proteinuria are usually seen. These …

Metabolic hormones are integral regulators of female reproductive health and function

F Athar, M Karmani, NM Templeman - Bioscience reports, 2024 - portlandpress.com
The female reproductive system is strongly influenced by nutrition and energy balance. It is
well known that food restriction or energy depletion can induce suppression of reproductive …

Integrated systems biology approach identifies novel maternal and placental pathways of preeclampsia

NG Than, R Romero, AL Tarca, KA Kekesi… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our
understanding of the complex interactions among their respective disease pathways …

Osteoarthritis and toll-like receptors: when innate immunity meets chondrocyte apoptosis

G Barreto, M Manninen, K K. Eklund - Biology, 2020 - mdpi.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Multiomic immune clockworks of pregnancy

LS Peterson, IA Stelzer, AS Tsai, MS Ghaemi… - Seminars in …, 2020 - Springer
Preterm birth is the leading cause of mortality in children under the age of five worldwide.
Despite major efforts, we still lack the ability to accurately predict and effectively prevent …

The role of leptin in fetal growth during pre-eclampsia

VE de Knegt, PL Hedley, JK Kanters… - International Journal of …, 2021 - mdpi.com
Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions
related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory …

The relationship between body mass index and preeclampsia: A systematic review and meta-analysis

M Motedayen, M Rafiei, MR Tavirani… - International journal …, 2019 - pmc.ncbi.nlm.nih.gov
Background One of the causes of maternal and fetal mortality and morbidity is pregnancy-
induced hypertension, the most common form of which is preeclampsia that causes many …

Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia

Y Song, J Gao, Y Qu, S Wang, X Wang, J Liu - Clinica chimica acta, 2016 - Elsevier
Background Alterations in serum adipokines in preeclampsia remain vague. We
investigated the roles of leptin, adiponectin and resistin and their relationships with clinical …

The role of serum adipokine levels in preeclampsia: a systematic review

G Daskalakis, I Bellos, M Nikolakea, V Pergialiotis… - Metabolism, 2020 - Elsevier
Background Preeclampsia represents a major pregnancy complication, associated with high
rates of perinatal morbidity. The aim of this systematic review is to accumulate current …

[HTML][HTML] A review of candidate genes and pathways in preeclampsia–an integrated bioinformatical analysis

MA Mohamad, NF Mohd Manzor, NF Zulkifli, N Zainal… - Biology, 2020 - mdpi.com
Preeclampsia is a pregnancy-specific disorder characterized by the presence of
hypertension with the onset of either proteinuria, maternal organ or uteroplacental …