CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Lactic acid production has been regarded as a mechanism by which malignant cells escape
immunosurveillance. Recent technological advances in mass spectrometry and the use of …

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and sha** immune outcomes. Here, we identified ketone bodies (KBs)—including β …

CD8+ T cell activation leads to the rapid proliferation and differentiation of effector T cells
(Teffs), which mediate antitumor immunity. Although aerobic glycolysis is preferentially …

Regular physical activity is associated with lower cancer incidence and mortality, as well as
with a lower rate of tumour recurrence. The epidemiological evidence is supported by …

CD8+ T cells control tumors but inevitably become dysfunctional in the tumor
microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell dysfunction …

The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the
monocarboxylate transporter symport system suppresses antitumor T cell immunity …

Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms,
from yeast to mammals, derive usable energy primarily through glycolysis and respiration …

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor
microenvironment (TME), metabolism dysfunction of the three should take the blame for …