The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

The nasal route has been used for many years for the local treatment of nasal diseases.
More recently, this route has been gaining momentum, due to the possibility of targeting the …

Inhalation therapy plays an important role in management or treatment of respiratory
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …

In vitro–in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally
inhaled drug based on in vitro drug measurements. In vitro measurements include physical …

Abstract Evaluation of the regional intranasal delivery of locally acting drugs in children is
challenging. Anatomical nasal airway replicas potentially can provide a robust pre-clinical …

Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …

Quantifying drug delivery to the site of action using locally-acting nasal suspension sprays is
a challenging but important step toward understanding bioequivalence (BE) between test …

In vitro nasal models can potentially facilitate development and approval of nasal drug
products. This study aims to evaluate the potential for using regional deposition …

Nose-to-brain delivery is a promising way to improve the treatment of central nervous system
disorders, as it allows the bypassing of the blood–brain barrier. However, it is still largely …

Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …