SARS-CoV-2 and the spike protein in endotheliopathy

L Perico, A Benigni, G Remuzzi - Trends in Microbiology, 2024 - cell.com
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …

Cardiovascular disease as part of Long COVID: A systematic review

V Tsampasian, M Bäck, M Bernardi… - European journal of …, 2024 - academic.oup.com
Aims Long COVID syndrome has had a major impact on million patients' lives worldwide.
The cardiovascular system is an important aspect of this multifaceted disease that may …

Diabetes mellitus, energy metabolism, and COVID-19

C Conte, E Cipponeri, M Roden - Endocrine Reviews, 2024 - academic.oup.com
Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …

[HTML][HTML] Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

K Wang, M Khoramjoo, K Srinivasan, PMK Gordon… - Cell Reports …, 2023 - cell.com
The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often
associated with debilitating symptoms and adverse multisystem consequences. We obtain …

[HTML][HTML] The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review

M Yousef, M Rob, S Varghese, S Rao, F Zamir, P Paul… - Life Sciences, 2024 - Elsevier
Aims Emerging evidence highlights the role of COVID-19 in instigating gut dysbiosis, with
repercussions on disease severity and bidirectional gut-organ communication involving the …

Sex differences in airway disease: estrogen and airway surface liquid dynamics

BJ Harvey, NG McElvaney - Biology of sex Differences, 2024 - Springer
Biological sex differences exist for many airway diseases in which females have either
worse or better health outcomes. Inflammatory airway diseases such as cystic fibrosis (CF) …

Gender differences in response to COVID-19 infection and vaccination

K Zaher, F Basingab, J Alrahimi, K Basahel… - Biomedicines, 2023 - mdpi.com
Since COVID-19 first appeared, a number of follow-up events have taken place. In an effort
to find a solution to this catastrophe, a great deal of study and analysis has been conducted …

Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis

CT Baldari, A Onnis, E Andreano, G Del Giudice… - Trends in …, 2023 - cell.com
The COVID-19 pandemic, caused by SARS-CoV-2, has caused an estimated 5 billion
infections and 20 million deaths by respiratory failure. In addition to the respiratory disease …

Discovery of highly potent covalent SARS-CoV-2 3CLpro inhibitors bearing 2-sulfoxyl-1, 3, 4-oxadiazole scaffold for combating COVID-19

FM Zhang, T Huang, F Wang, GS Zhang, D Liu… - European Journal of …, 2023 - Elsevier
Abstract The coronavirus disease (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a major public health …

DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner

MS Strine, WL Cai, J Wei, MM Alfajaro, RB Filler… - Plos …, 2023 - journals.plos.org
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …