Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …

The complement system is a major component of the immune system and plays a central
role in many protective immune processes, including circulating immune complex …

Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …

The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …

Objectives Spondyloarthritides (SpA) are characterised by both peripheral and axial arthritis.
The hallmarks of peripheral SpA are the development of enthesitis, most typically of the …

Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis.
Despite the inherent limitations of all animal models, several rodent models have …

Reduced capacity to produce ROS increases the severity of T cell–dependent arthritis in
both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1)(p47phox) …

Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship
between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long …

Interleukin 17 is a T cell‐derived cytokine that induces the release of pro‐inflammatory
mediators in a wide range of cell types. Recently, a subset of IL‐17‐producing T helper cells …

Rheumatoid arthritis–associated joint pain is frequently observed independent of disease
activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding …