Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications
Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth
factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in …
factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in …
Mechanisms of photoaging and chronological skin aging
Human skin, like all other organs, undergoes chronological aging. In addition, unlike other
organs, skin is in direct contact with the environment and therefore undergoes aging as a …
organs, skin is in direct contact with the environment and therefore undergoes aging as a …
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling
Protein phosphorylation plays a cardinal role in regulating many cellular processes in
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …
eukaryotes. In particular, protein phosphorylation is a major currency of signal transduction …
Cellular functions regulated by Src family kinases
▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …
different classes of cellular receptors and participate in signaling pathways that control a …
The molecular biology of axon guidance
Neuronal growth cones navigate over long distances along specific pathways to find their
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of …
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of …
Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases
Plant receptor-like kinases (RLKs) are proteins with a predicted signal sequence, single
transmembrane region, and cytoplasmic kinase domain. Receptor-like kinases belong to a …
transmembrane region, and cytoplasmic kinase domain. Receptor-like kinases belong to a …
[HTML][HTML] ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
D Graus‐Porta, RR Beerli, JM Daly, NE Hynes - The EMBO journal, 1997 - embopress.org
We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)‐
related peptides in cell lines naturally expressing the four ErbB receptors. Down‐regulation …
related peptides in cell lines naturally expressing the four ErbB receptors. Down‐regulation …
Comparative analysis of the receptor-like kinase family in Arabidopsis and rice
Receptor-like kinases (RLKs) belong to the large RLK/Pelle gene family, and it is known that
the Arabidopsis thaliana genome contains> 600 such members, which play important roles …
the Arabidopsis thaliana genome contains> 600 such members, which play important roles …
UV-light-induced signal cascades and skin aging
UV irradiation acts as a broad activator of cell surface growth factor and cytokine receptors.
This ligand-independent receptor activation induces multiple downstream signaling …
This ligand-independent receptor activation induces multiple downstream signaling …
[کتاب][B] Bioassay techniques for drug development
MI Choudhary, WJ Thomsen - 2001 - taylorfrancis.com
The goal of an activity-directed isolation process is to isolate bioactive compounds which
may provide structural leads of therapeutic importance. Whereas the traditional process of …
may provide structural leads of therapeutic importance. Whereas the traditional process of …