Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression

TT van Sloten, S Sedaghat, MR Carnethon… - The lancet Diabetes & …, 2020 - thelancet.com
Adults with type 2 diabetes are at an increased risk of develo** certain brain or mental
disorders, including stroke, dementia, and depression. Although these disorders are not …

[HTML][HTML] Emerging concepts in vascular dementia: a review

SC Bir, MW Khan, V Javalkar, EG Toledo… - Journal of Stroke and …, 2021 - Elsevier
Abstract Objective Vascular dementia (VaD) is the second most common cause of dementia
and a major health concern worldwide. A comprehensive review on VaD is warranted for …

Genetics of common cerebral small vessel disease

C Bordes, M Sargurupremraj, A Mishra… - Nature Reviews …, 2022 - nature.com
Cerebral small vessel disease (cSVD) is a leading cause of ischaemic and haemorrhagic
stroke and a major contributor to dementia. Covert cSVD, which is detectable with brain MRI …

Stroke genetics: discovery, biology, and clinical applications

M Dichgans, SL Pulit, J Rosand - The Lancet Neurology, 2019 - thelancet.com
Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …

Cardiovascular comorbidities, inflammation, and cerebral small vessel disease

LE Evans, JL Taylor, CJ Smith… - Cardiovascular …, 2021 - academic.oup.com
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Risk factors for cognitive impairment and dementia after stroke: a systematic review and meta-analysis

J Filler, MK Georgakis, M Dichgans - The Lancet Healthy Longevity, 2024 - thelancet.com
Background Cognitive impairment and dementia are highly prevalent among stroke
survivors and represent a major burden for patients, carers, and health-care systems. We …

Genetics insights in the relationship between type 2 diabetes and coronary heart disease

MO Goodarzi, JI Rotter - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …

Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study

MK Georgakis, EL Harshfield, R Malik, N Franceschini… - Neurology, 2021 - AAN Enterprises
Objective We employed Mendelian randomization to explore the effects of genetic
predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and pancreatic β …

Relationship between type 2 diabetes and white matter hyperintensity: a systematic review

DQ Wang, L Wang, MM Wei, XS **a, XL Tian… - Frontiers in …, 2020 - frontiersin.org
White matter (WM) disease is recognized as an important cause of cognitive decline and
dementia. White matter lesions (WMLs) appear as white matter hyperintensities (WMH) on …