RNA in cancer
GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
[HTML][HTML] CLIP and complementary methods
RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
m6A modification in RNA: biogenesis, functions and roles in gliomas
Y Zhang, X Geng, Q Li, J Xu, Y Tan, M **ao… - Journal of Experimental …, 2020 - Springer
The chemical modification of RNA is a newly discovered epigenetic regulation mechanism
in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) …
in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) …
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing
CJ Herrmann, R Schmidt, A Kanitz, P Artimo… - Nucleic acids …, 2020 - academic.oup.com
Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly
(A)) sites, alternative terminal exons account for much of the variation between human …
(A)) sites, alternative terminal exons account for much of the variation between human …
The emerging roles of RNA modifications in glioblastoma
Z Dong, H Cui - Cancers, 2020 - mdpi.com
Glioblastoma (GBM) is a grade IV glioma that is the most malignant brain tumor type.
Currently, there are no effective and sufficient therapeutic strategies for its treatment …
Currently, there are no effective and sufficient therapeutic strategies for its treatment …
Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the
regulation of gene expression and cellular functions. Dysregulation of these interactions has …
regulation of gene expression and cellular functions. Dysregulation of these interactions has …
On the function and relevance of alternative 3′‐UTRs in gene expression regulation
I Pereira‐Castro, A Moreira - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Messanger RNA (mRNA) isoforms with alternative 3′‐untranslated regions (3′‐UTRs) are
produced by alternative polyadenylation (APA), which occurs during transcription in most …
produced by alternative polyadenylation (APA), which occurs during transcription in most …
Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data
S Bryce-Smith, D Burri, MR Gazzara, CJ Herrmann… - RNA, 2023 - rnajournal.cshlp.org
The tremendous rate with which data is generated and analysis methods emerge makes it
increasingly difficult to keep track of their domain of applicability, assumptions, limitations …
increasingly difficult to keep track of their domain of applicability, assumptions, limitations …
Alternative polyadenylation: methods, mechanism, function, and role in cancer
Occurring in over 60% of human genes, alternative polyadenylation (APA) results in
numerous transcripts with differing 3'ends, thus greatly expanding the diversity of mRNAs …
numerous transcripts with differing 3'ends, thus greatly expanding the diversity of mRNAs …