Epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial transition (MET) plays
critical roles in cancer metastasis. Recent studies, especially those based on single‐cell …

Immune checkpoint blockage has been considered a breakthrough in cancer treatment,
achieving encouraging anti-tumor effects in some advanced solid malignancies. However …

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses
immersed in aberrant communication circuits that facilitate tumor growth and dissemination …

Maintaining the balance between eliciting immune responses against foreign proteins and
tolerating self-proteins is crucial for maintenance of homeostasis. The functions of …

Currently, metastasis remains the primary cause of death of patients with breast cancer
despite the important advances in the treatment of this disease. In the complex tumour …

Fibrosis is a pathological tissue repair activity in which many myofibroblasts are activated
and extracellular matrix are excessively accumulated, leading to the formation of permanent …

Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a
predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with …

Metastasis is known as the most life-threatening event in cancer patients. In principle, the
immune system can prevent tumor development. However, dysfunctional T cells may fail to …

Over the last decade, both early diagnosis and targeted therapy have improved the survival
rates of many cancer patients. Most recently, immunotherapy has revolutionized the …

Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9
(CRISPR/Cas9) gene editing technology implements precise programming of the human …