Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …

The pace of technological innovation over the past three decades has transformed the field
of radiotherapy into one of the most technologically intense disciplines in medicine …

Abstract Background Elevated microRNA-155 (miR-155) expression in non-small-cell lung
cancer (NSCLC) promotes cisplatin resistance and negatively impacts treatment outcomes …

Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of develo** personalized treatment strategies based on individual patient …

Immunotherapy has become a fourth pillar in the treatment of brain tumors and, when
combined with radiation therapy, may improve patient outcomes and reduce the …

Purpose To develop a comprehensive framework to simulate the response to immune
checkpoint inhibitors (ICIs) in combination with radiation therapy (RT) and to apply the …

Hepatocellular carcinoma (HCC) is the most common liver cancer and one of the leading
causes of cancer-related deaths in the world. Multiple immunotherapeutic approaches have …

Breast cancer is the most prominent type of cancer among women. Understanding the
microenvironment of breast cancer and the interactions between cells and cytokines will …

A low response rate is the major challenge for existing cancer immunotherapies. Physical
cues in the tumor microenvironment (TME) have been recognized as new hallmarks of …

Brain metastases (BMs) are the most common intracranial tumor type and a significant
health concern, affecting approximately 10% to 30% of all oncological patients. Although …