Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations
Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …
Who is who in adenosine transport
Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …
Gestational diabesity and foetoplacental vascular dysfunction
Gestational diabetes mellitus (GDM) shows a deficiency in the metabolism of D‐glucose and
other nutrients, thereby negatively affecting the foetoplacental vascular endothelium …
other nutrients, thereby negatively affecting the foetoplacental vascular endothelium …
Transporter regulation in critical protective barriers: focus on brain and placenta
V Taggi, M Riera Romo, M Piquette-Miller… - Pharmaceutics, 2022 - mdpi.com
Drug transporters play an important role in the maintenance of chemical balance and
homeostasis in different tissues. In addition to their physiological functions, they are crucial …
homeostasis in different tissues. In addition to their physiological functions, they are crucial …
Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes
Human endothelial dysfunction is a common feature in many diseases of pregnancy, such
as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide …
as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide …
Insulin restores gestational diabetes mellitus–reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein …
OBJECTIVE To determine whether insulin reverses gestational diabetes mellitus (GDM)–
reduced expression and activity of human equilibrative nucleoside transporters 1 (hENT1) in …
reduced expression and activity of human equilibrative nucleoside transporters 1 (hENT1) in …
Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes …
Gestational diabetes mellitus (GDM) and obesity in pregnancy (OP) are pathological
conditions associated with placenta vascular dysfunction coursing with metabolic changes …
conditions associated with placenta vascular dysfunction coursing with metabolic changes …
Insulin/adenosine axis linked signalling
Regulation of blood flow depends on systemic and local release of vasoactive molecules
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …
Adenosine contribution to normal renal physiology and chronic kidney disease
Adenosine is a nucleoside that is particularly interesting to many scientific and clinical
communities as it has important physiological and pathophysiological roles in the kidney …
communities as it has important physiological and pathophysiological roles in the kidney …
Gestational diabetes reduces adenosine transport in human placental microvascular endothelium, an effect reversed by insulin
Gestational diabetes mellitus (GDM) courses with increased fetal plasma adenosine
concentration and reduced adenosine transport in placental macrovascular endothelium …
concentration and reduced adenosine transport in placental macrovascular endothelium …