Age, APOE and sex: triad of risk of Alzheimer's disease
Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization
IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
The vascular depression hypothesis: mechanisms linking vascular disease with depression
Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease
The evident genetic, pathological and clinical heterogeneity of Alzheimer's disease (AD)
poses challenges for traditional drug development. We conducted a computational drug …
poses challenges for traditional drug development. We conducted a computational drug …
What did you do yesterday? A meta-analysis of sex differences in episodic memory.
To remember what one did yesterday is an example of an everyday episodic memory task,
in which a female advantage has sometimes been reported. Here, we quantify the impact of …
in which a female advantage has sometimes been reported. Here, we quantify the impact of …
Preventing dementia? Interventional approaches in mild cognitive impairment
V Lissek, B Suchan - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Mild cognitive impairment (MCI) is defined as an intermediate state between normal
cognitive aging and dementia. It describes a status of the subjective impression of cognitive …
cognitive aging and dementia. It describes a status of the subjective impression of cognitive …
APOE genotype and Alzheimer's disease: the influence of lifestyle and environmental factors
Alzheimer's disease (AD) is the most common neurodegenerative disorder with obscure
pathogenesis and no disease-modifying therapy to date. AD is multifactorial disease that …
pathogenesis and no disease-modifying therapy to date. AD is multifactorial disease that …
Cognitive enhancement by drugs in health and disease
Attempts to improve cognitive function in patients with brain disorders have become the
focus of intensive research efforts. A recent emerging trend is the use of so-called cognitive …
focus of intensive research efforts. A recent emerging trend is the use of so-called cognitive …
Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial
Objective: To preliminarily assess the safety and efficacy of transdermal nicotine therapy on
cognitive performance and clinical status in subjects with mild cognitive impairment (MCI) …
cognitive performance and clinical status in subjects with mild cognitive impairment (MCI) …
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional–executive network function in Alzheimer's disease
The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for
Alzheimer's disease (AD), but limited work has suggested that APOE genotype may …
Alzheimer's disease (AD), but limited work has suggested that APOE genotype may …