Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …
kinases'. It phosphorylates and inhibits eukaryotic elongation factor 2, to slow down the …
Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases
Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates
the elongation stage of protein synthesis by phosphorylating and inhibiting its only known …
the elongation stage of protein synthesis by phosphorylating and inhibiting its only known …
In vitro methods for testing antiviral drugs
M Rumlová, T Ruml - Biotechnology advances, 2018 - Elsevier
Despite successful vaccination programs and effective treatments for some viral infections,
humans are still losing the battle with viruses. Persisting human pandemics, emerging and …
humans are still losing the battle with viruses. Persisting human pandemics, emerging and …
Synthesis and biological evaluation of pyrido [2, 3-d] pyrimidine-2, 4-dione derivatives as eEF-2K inhibitors
R Edupuganti, Q Wang, CDJ Tavares… - Bioorganic & medicinal …, 2014 - Elsevier
A small molecule library of pyrido [2, 3-d] pyrimidine-2, 4-dione derivatives 6–16 was
synthesized from 6-amino-1, 3-disubstituted uracils 18, characterized, and screened for …
synthesized from 6-amino-1, 3-disubstituted uracils 18, characterized, and screened for …
Designing an eEF2K-targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells
Y Liu, Y Zhen, G Wang, G Yang, L Fu, B Liu… - European Journal of …, 2020 - Elsevier
Eukaryotic elongation factor 2 kinase (eEF2K) is a key α-kinase that negatively regulates the
extension step of protein synthesis, which consumes most of the energy and amino acids …
extension step of protein synthesis, which consumes most of the energy and amino acids …
Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase
A Piserchio, EA Isiorho, K Long, AL Bohanon… - Science …, 2022 - science.org
Translation is a tightly regulated process that ensures optimal protein quality and enables
adaptation to energy/nutrient availability. The α-kinase eukaryotic elongation factor 2 kinase …
adaptation to energy/nutrient availability. The α-kinase eukaryotic elongation factor 2 kinase …
ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin
A Piserchio, KJ Long, LS Browning… - Proceedings of the …, 2023 - National Acad Sciences
Protein translation, one of the most energy-consumptive processes in a eukaryotic cell,
requires robust regulation, especially under energy-deprived conditions. A critical …
requires robust regulation, especially under energy-deprived conditions. A critical …
Eukaryotic elongation factor-2 kinase (eEF2K): a potential therapeutic target in cancer
LL Fu, T **e, SY Zhang, B Liu - Apoptosis, 2014 - Springer
Eukaryotic elongation factor-2 kinase (eEF2K), encoded by the EEF2K gene, is well-known
to be a Ca 2+/calmodulin (CaM)-dependent kinase which can negatively modulate protein …
to be a Ca 2+/calmodulin (CaM)-dependent kinase which can negatively modulate protein …
Translational control in brain pathologies: biological significance and therapeutic opportunities
Messenger RNA (mRNA) translation is the terminal step in protein synthesis, providing a
crucial regulatory checkpoint for this process. Translational control allows specific cell types …
crucial regulatory checkpoint for this process. Translational control allows specific cell types …
Inhibiting eukaryotic elongation factor 2 kinase: an update on pharmacological small-molecule compounds in cancer
S Zhu, M Liao, H Tan, L Zhu, Y Chen… - Journal of medicinal …, 2021 - ACS Publications
Eukaryotic elongation factor 2 kinase (eEF2K), a member of the atypical protein kinase
family of alpha-kinases, is well-known as a negative regulator of protein synthesis by …
family of alpha-kinases, is well-known as a negative regulator of protein synthesis by …