Intratumoral heterogeneity in glioblastoma: don't forget the peritumoral brain zone
JM Lemée, A Clavreul, P Menei - Neuro-oncology, 2015 - academic.oup.com
Glioblastoma (GB) is the most frequent and aggressive primary tumor of the central nervous
system. Prognosis remains poor despite ongoing progress. In cases where the gadolinium …
system. Prognosis remains poor despite ongoing progress. In cases where the gadolinium …
Recent advances in the molecular understanding of glioblastoma
Glioblastoma is the most common and most aggressive primary brain tumor. Despite
maximum treatment, patients only have a median survival time of 15 months, because of the …
maximum treatment, patients only have a median survival time of 15 months, because of the …
[HTML][HTML] Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
Two recurrent mutations, K27M and G34R/V, within histone variant H3. 3 were recently
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …
IFN‐γ promotes transendothelial migration of CD4+ T cells across the blood–brain barrier
Transendothelial migration (TEM) of Th1 and Th17 cells across the blood–brain barrier
(BBB) has a critical role in the development of experimental autoimmune encephalomyelitis …
(BBB) has a critical role in the development of experimental autoimmune encephalomyelitis …
Illuminating radiogenomic characteristics of glioblastoma multiforme through integration of MR imaging, messenger RNA expression, and DNA copy number variation
Purpose To perform a multilevel radiogenomics study to elucidate the glioblastoma
multiforme (GBM) magnetic resonance (MR) imaging radiogenomic signatures resulting …
multiforme (GBM) magnetic resonance (MR) imaging radiogenomic signatures resulting …
A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis
A Volk, K Liang, P Suraneni, X Li, J Zhao, M Bulic… - Cancer cell, 2018 - cell.com
CHAF1B is the p60 subunit of the chromatin assembly factor (CAF1) complex, which is
responsible for assembly of histones H3. 1/H4 heterodimers at the replication fork during S …
responsible for assembly of histones H3. 1/H4 heterodimers at the replication fork during S …
A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma
Purpose: Increased mitogenic signaling and angiogenesis, frequently facilitated by somatic
activation of EGF receptor (EGFR; ErbB1) and/or loss of PTEN, and VEGF overexpression …
activation of EGF receptor (EGFR; ErbB1) and/or loss of PTEN, and VEGF overexpression …
[HTML][HTML] 'From the core to beyond the margin': a genomic picture of glioblastoma intratumor heterogeneity
Glioblastoma (GB) is a highly invasive primary brain tumor that almost systematically recurs
despite aggressive therapies. One of the most challenging problems in therapy of GB is its …
despite aggressive therapies. One of the most challenging problems in therapy of GB is its …
HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways
T Chen, H Huang, Y Zhou, L Geng, T Shen… - Journal of Experimental …, 2018 - Springer
Background Holliday junction recognition protein (HJURP) has been implicated in many
cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by …
cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by …
Histone variants: guardians of genome integrity
J Ferrand, B Rondinelli, SE Polo - Cells, 2020 - mdpi.com
Chromatin integrity is key for cell homeostasis and for preventing pathological development.
Alterations in core chromatin components, histone proteins, recently came into the spotlight …
Alterations in core chromatin components, histone proteins, recently came into the spotlight …