Fertility in mammals is ultimately controlled by a small population of neurons–the
gonadotropin-releasing hormone (GnRH) neurons–located in the ventral forebrain. GnRH …

Stress is well-known to inhibit a variety of reproductive processes, including the suppression
of episodic Gonadotropin releasing hormone (GnRH) secretion, typically measured via …

Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin
B and dynorphin (KNDy cells) are essential for mammalian reproduction as key regulators of …

The normal function of the mammalian reproductive axis is strongly influenced by
physiological, metabolic and environmental factors. Kisspeptin neuropeptides, encoded by …

Kisspeptin neurons located in the hypothalamic arcuate nucleus are thought to represent the
GnRH pulse generator responsible for driving pulsatile LH secretion. The recent …

Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve
activity (SNA) is unclear, since PVN leptin receptors (LepR) are sparse. We show in rats that …

Acute stress is a potent suppressor of pulsatile luteinizing hormone (LH) secretion, but the
mechanisms through which corticotrophin-releasing hormone (CRH) neurons inhibit …

The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …

Adverse energy states exert a potent suppressive influence on the reproductive axis by
inhibiting the pulsatile release of gonadotrophin‐releasing hormone and luteinising …

The arcuate nucleus kisspeptin (ARNKISS) neurons represent the GnRH pulse generator
that likely drives pulsatile gonadotropin secretion in all mammals. Using an improved …