The serum-and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and
under genomic control by cell stress (including cell shrinkage) and hormones (including …

Regulated Na+ transport in the distal nephron is of fundamental importance to fluid and
electrolyte homeostasis. Further upstream, Na+ is the principal driver of secondary active …

Sodium transport in epithelial tissues is regulated by the physiological mineralocorticoid
aldosterone. The response to aldosterone is mediated by the mineralocorticoid receptor …

The last decade has witnessed tremendous progress in the understanding of the
mineralocorticoid receptor (MR), its molecular mechanism of action, and its implications for …

Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in
the adrenal cortex. It regulates a variety of physiological responses including those to …

Aldosterone concentrations are inappropriately high in many patients with hypertension, as
well as in an increasing number of individuals with metabolic syndrome and sleep apnoea …

Metabolic syndrome is an important risk factor for proteinuria and chronic kidney disease
independent of diabetes and hypertension; however, the underlying mechanisms have not …

A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the
acknowledged authority on renal physiology and pathophysiology. The fourth edition follows …

Until relatively recently, the mineralocorticoid hormone aldosterone was thought to be
produced uniquely in the adrenal cortex and to act exclusively on epithelia to promote …

Stress represents the main environmental risk factor for mental illness. Exposure to stressful
events, particularly early in life, has been associated with increased incidence and …