Multiplexed imaging in oncology

C Andreou, R Weissleder, MF Kircher - Nature Biomedical Engineering, 2022 - nature.com
In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …

Biological imaging of chemical bonds by stimulated Raman scattering microscopy

F Hu, L Shi, W Min - Nature methods, 2019 - nature.com
All molecules consist of chemical bonds, and much can be learned from map** the
spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated …

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK

Y Li, D Munoz-Mayorga, Y Nie, N Kang, Y Tao… - Cell metabolism, 2024 - cell.com
The accumulation of lipid droplets (LDs) in aging and Alzheimer's disease brains is
considered a pathological phenomenon with unresolved cellular and molecular …

Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning

Y Rivenson, H Wang, Z Wei, K de Haan… - Nature biomedical …, 2019 - nature.com
The histological analysis of tissue samples, widely used for disease diagnosis, involves
lengthy and laborious tissue preparation. Here, we show that a convolutional neural network …

Super-resolution SRS microscopy with A-PoD

H Jang, Y Li, AA Fung, P Bagheri, K Hoang… - Nature …, 2023 - nature.com
Stimulated Raman scattering (SRS) offers the ability to image metabolic dynamics with high
signal-to-noise ratio. However, its spatial resolution is limited by the numerical aperture of …

Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

JX Cheng, XS **e - Science, 2015 - science.org
BACKGROUND Biomolecules can serve as natural labels for microscopy by measuring their
molecular vibration spectra in living cells and tissues. However, the transition from …

Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Z Liu, W Su, J Ao, M Wang, Q Jiang, J He, H Gao… - Nature …, 2022 - nature.com
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but the
gold standard histopathology is time-consuming and incompatible with gastroscopy …

Raman spectroscopy: techniques and applications in the life sciences

DW Shipp, F Sinjab, I Notingher - Advances in Optics and Photonics, 2017 - opg.optica.org
Raman spectroscopy is an increasingly popular technique in many areas, including biology
and medicine. It is based on Raman scattering, a phenomenon in which incident photons …

High-resolution, high-contrast mid-infrared imaging of fresh biological samples with ultraviolet-localized photoacoustic microscopy

J Shi, TTW Wong, Y He, L Li, R Zhang, CS Yung… - Nature …, 2019 - nature.com
Mid-infrared (MIR) microscopy provides rich chemical and structural information about
biological samples, without staining. Conventionally, the long MIR wavelength severely …

Raman spectroscopy and imaging in bioanalytics

D Cialla-May, C Krafft, P Rösch… - Analytical …, 2021 - ACS Publications
Since the discovery of the inelastic scattering of light, ie, the so-called Raman effect, 1
Raman spectroscopy has become an attractive tool in a high number of research fields …