[HTML][HTML] The METTL3-m6A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer

A Maldonado López, BC Capell - Genes, 2021 - mdpi.com
Dynamic modifications on RNA, frequently termed both,“RNA epigenetics” and
“epitranscriptomics”, offer one of the most exciting emerging areas of gene regulation and …

N6-methyladenosine RNA modification in head and neck squamous cell carcinoma (HNSCC): current status and future insights

P Janakiraman, JP Jayaprakash, SV Muralidharan… - Medical Oncology, 2024 - Springer
Abstract N6-methyladenosine (m6A) plays a pivotal role in regulating epitranscriptomic
mechanisms and is closely linked to the normal functioning of diverse classes of RNAs, both …

KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization

N Li, Z Zhu, Y Deng, R Tang, H Hui, Y Kang… - EMBO …, 2023 - embopress.org
Abstract N6‐methyladenosine (m6A), the most abundant internal modification in eukaryotic
mRNA, plays important roles in many physiological and pathological processes, including …

DYNC1I1 acts as a promising prognostic biomarker and is correlated with immune infiltration in head and neck squamous cell carcinoma

RG Ananya, C Pandi, B Kannan, A Pandi… - Journal of Stomatology …, 2024 - Elsevier
Abstract Background/purpose Dynein Cytoplasmic 1 Intermediate Chain 1 (DYNC1I1) is a
crucial cytoplasmic dynein binding component, its high expression levels are associated …

METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in …

X Li, J **, X Long, R Weng, W **ong, J Liang… - Reproductive Biology …, 2023 - Springer
Background Endometriosis-related infertility is a common worldwide reproductive health
concern. Despite ongoing research, the causes of infertility remain unclear. Evidence …

METTL3 inhibitor STM2457 impairs tumor progression and enhances sensitivity to anlotinib in OSCC

L Liu, T Zhao, S Zheng, D Tang, H Han, C Yang… - Oral …, 2024 - Wiley Online Library
Objectives To investigate the inhibitory effects of STM2457, which is a novel METTL3 (m6A
writer) inhibitor, both as a monotherapy and in combination with anlotinib, in the treatment of …

Prognostic and clinicopathological significance of MRC2 expression in head and neck squamous cell carcinoma

K vinayakam Gopalakrishnan, B Kannan… - Journal of Stomatology …, 2023 - Elsevier
Background Head and neck squamous cell carcinoma (HNSCC) is one of the most
aggressive types of cancers worldwide, with metastasis being the major cause of death …

Extraction, characterization, and anticancer potential of extracellular polymeric substances from marine actinobacteria of Streptomyces species

ZM Noufal, P Sivaperumal… - Journal of advanced …, 2022 - journals.lww.com
To check the ability of the anticancer activity, the extracted extracellular polymeric
substances (EPS) from marine actinobacteria were done. Potential of the anticancer activity …

Oral squamous cell carcinoma gene patterns connected with RNA methylation for prognostic prediction

X Wu, J Tang, B Cheng - Oral Diseases, 2024 - Wiley Online Library
Objectives To determine whether m6A/m1A/m5C/m7G/m6Am/Ψ‐related genes influence the
prognosis of a patient with oral squamous cell carcinoma. Materials and Methods We …

Knowledge and awareness on various treatment modalities of diabetes mellitus-a observational survey

R Prasath, P Sinduja - 2023 - digibug.ugr.es
Introduction: Diabetes mellitus (DM) is a group of metabolic disorders characterized by a
high blood sugar level over a prolonged period of time. Patients suffer from various …