RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

With the growth of protein structure data, the analysis of molecular interactions between
ligands and their target molecules is gaining importance. PLIP, the protein–ligand …

Circular RNAs (circRNAs) are covalently closed, endogenous RNAs with no 5′ end caps or
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …

Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …

INTRODUCTION Cytoplasmic face of the human NPC. Near-atomic composite structure of
the NPC generated by docking high-resolution crystal structures into a cryo‑ET …

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

Many biomolecular condensates are enriched in and depend on RNAs and RNA binding
proteins (RBPs). So far, only a few studies have addressed the characterization of the …

The RNA-binding protein FUS (Fused in Sarcoma) mediates phase separation in
biomolecular condensates and functions in transcription by clustering with RNA polymerase …