Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …

Cartilage is a hydrated biomacromolecular fiber composite located at the ends of long bones
that enables proper joint lubrication, articulation, loading, and energy dissipation …

Joint biomechanical functions rely on the integrity of cartilage extracellular matrix.
Understanding the molecular activities that govern cartilage matrix assembly is critical for …

Stick-slip friction was observed in articular cartilage under certain loading and sliding
conditions and systematically studied. Using the Surface Forces Apparatus, we show that …

The importance, and the difficulty, of generating biosynthetic articular cartilage is widely
recognized. Problems arise from obtaining sufficient stiffness, toughness and longevity in the …

Aggrecan is a high-molecular-weight, bottlebrush-shaped, negatively charged biopolymer
that forms supermolecular complexes with hyaluronic acid. In the extracellular matrix of …

This work reports on the formation and characterization of a novel hydrogel based on the
polysaccharide alginate physically crosslinked by calcium ions (Ca2+) in the presence of …

In this study, atomic force microscopy-based dynamic oscillatory and force-relaxation
indentation was employed to quantify the time-dependent nanomechanics of native …

Chondroitin sulfate is a major constituent of articular cartilage, which is known to affect in a
decisive way the mobility and flexibility of our joints. A deviation from the physiological …

Polyelectrolyte multilayer films assembled from a hydrophobic N-alkylated polyethylenimine
and a hydrophilic polyacrylate were discovered to exhibit strong antifouling, as well as …