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Host-directed immunotherapy of viral and bacterial infections: past, present and future
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
Overview of immune response during SARS-CoV-2 infection: lessons from the past
After the 1918 flu pandemic, the world is again facing a similar situation. However, the
advancement in medical science has made it possible to identify that the novel infectious …
advancement in medical science has made it possible to identify that the novel infectious …
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated …
progression that suggest diverse host immune responses. We performed an integrated …
Interplay between SARS-CoV-2 and the type I interferon response
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …
Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with> 4,000,000
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …
Role of inflammatory cytokines in COVID-19 patients: a review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …
The interferon landscape along the respiratory tract impacts the severity of COVID-19
Summary Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction
of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) …
of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) …
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Abstract The chr12q24. 13 locus encoding OAS1–OAS3 antiviral proteins has been
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …
[HTML][HTML] The immune response to SARS-CoV-2 and COVID-19 immunopathology–current perspectives
JL Boechat, I Chora, A Morais, L Delgado - Pulmonology, 2021 - Elsevier
SARS-CoV-2 is a new beta coronavirus, similar to SARS-CoV-1, that emerged at the end of
2019 in the Hubei province of China. It is responsible for coronavirus disease 2019 (COVID …
2019 in the Hubei province of China. It is responsible for coronavirus disease 2019 (COVID …
Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …
Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …