Dexmedetomidine is an α 2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic,
and analgesic-sparing effects, and minimal depression of respiratory function. It is potent …

Abstract Purpose of Review Effective acute pain management has evolved considerably in
recent years and is a primary area of focus in attempts to defend against the opioid …

Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic …

Afonso J, Reis F–Dexmedetomidine: Current Role in Anesthesia and Intensive Care.
Background and objectives: To update and review the application of dexmedetomidine in …

Dexmedetomidine is a useful medication with many clinical applications. The medication
has shown efficacy in decreasing the need for opioids, benzodiazepines, propofol, and other …

Despite lack of paediatric labelling, contributions to the literature on paediatric applications
of dexmedetomidine have increased over recent years. Dexmedetomidine possesses many …

The pharmacokinetic behavior of medicines used in humans follows largely predictable
patterns across the human age range from premature babies to elderly adults. Most of the …

Dexmedetomidine is a new generation highly selective α2-adrenergic receptor (α2-AR)
agonist that is associated with sedative and analgesic sparing effects, reduced delirium and …

Alpha (α)-2-Adrenergic receptor (AR) agonists have been the focus of interest for their
sedative, analgesic, perioperative sympatholytic, anesthetic-sparing, and hemodynamic …

Dexmedetomidine is an alpha 2 adrenergic receptor agonist, even ten times more selective
than clonidine. It is a very versatile drug in anaesthesia practice, finding place in increasing …