MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …

During the last decade, it has become clear that aberrant microRNA expression has a
functional role in the initiation and progression of colorectal cancer (CRC). Specific …

In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high
levels in lymphoid malignancies. In a model for p185 BCR-ABL+ B-acute lymphoid …

MicroRNAs (miRNAs) are recognized as being central players in many biological processes
and cellular pathways. Their roles in disease have been highlighted first by observation of …

microRNAs (miRNAs) are non coding RNAs with different biological functions and
pathological implications. Given their role as post-transcriptional gene expression …

Cancer is a complex disease involving alterations of multiple processes, with both genetic
and epigenetic features contributing as core factors to the disease. In recent years, it has …

The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

microRNAs take their place into the epigenetic world revealing a complicated network of
reciprocal interconnections: not only they are able to control gene expression at a post …

DNA methylation plays a key role in the silencing of numerous cancer-related genes,
thereby affecting a number of vital cellular processes, including the cell cycle checkpoint …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …