Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Copper is an essential trace element in biological systems, maintaining the activity of
enzymes and the function of transcription factors. However, at high concentrations, copper …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …

Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Although transition metals constitute less than 0.1% of the total mass within a human body,
they have a substantial impact on fundamental biological processes across all kingdoms of …

Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Recent studies have established a strong link between copper and cancer biology, as
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …

Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments,
such as oxidative stress. The copper chelator elesclomol has been reported to have …