COVID-19 vaccine development: milestones, lessons and prospects

M Li, H Wang, L Tian, Z Pang, Q Yang… - Signal transduction and …, 2022 - nature.com
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …

A comprehensive review of the global efforts on COVID-19 vaccine development

Y Li, R Tenchov, J Smoot, C Liu, S Watkins… - ACS Central …, 2021 - ACS Publications
A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development | ACS
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Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

AA Cohen, N van Doremalen, AJ Greaney, H Andersen… - Science, 2022 - science.org
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …

Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

AA Cohen, PNP Gnanapragasam, YE Lee, PR Hoffman… - Science, 2021 - science.org
Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
SARS-related emergent zoonotic coronaviruses is urgently needed. We made homotypic …

Scientific rationale for develo** potent RBD-based vaccines targeting COVID-19

H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

Challenges and developments in universal vaccine design against SARS-CoV-2 variants

F Zhao, X Zai, Z Zhang, J Xu, W Chen - npj Vaccines, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had
become a global concern because of its unexpectedly high pathogenicity and …

An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice

E Nanishi, F Borriello, TR O'Meara… - Science translational …, 2021 - science.org
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …

Current and future nanoparticle vaccines for COVID-19

MN Vu, HG Kelly, SJ Kent, AK Wheatley - EBioMedicine, 2021 - thelancet.com
COVID-19 has become a major cause of global mortality and driven massive health and
economic disruptions. Mass global vaccination offers the most efficient pathway towards …

Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

YF Kang, C Sun, J Sun, C **e, Z Zhuang, HQ Xu… - Nature …, 2022 - nature.com
Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike
protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike …