Uterine contractions in labor result in a 60% reduction in uteroplacental perfusion, causing
transient fetal and placental hypoxia. A healthy term fetus with a normally developed …

Highlights•Cardiotocographic (CTG) analyses of fetal baseline heart rate, accelerations,
variability and decelerations.•Physiology-based CTG interpretation identifies the following …

Acute neonatal encephalopathy remains a significant cause of death and long-term
disability. 1 Despite the highly adverse outcomes of moderate to severe encephalopathy …

Key points The in vivo fetal cardiovascular defence to chronic hypoxia has remained by and
large an enigma because no technology has been available to induce significant and …

Preterm fetuses and newborns have a high risk of neural injury and impaired neural
maturation, leading to neurodevelopmental disability. Develo** effective treatments is …

Spontaneous antenatal hypoxia is associated with high risk of adverse outcomes, however,
there is little information on neural adaptation to labor-like insults. Chronically instrumented …

Results: Total EEG power was profoundly suppressed after umbilical cord occlusion and
recovered to baseline by 5 h after 15-min of occlusion, in contrast with transient recovery in …

Perinatal anoxia remains an important public health problem as it can lead to hypoxic–
ischaemic encephalopathy (HIE) and cause significant neonatal mortality and morbidity. The …

Baseline fetal heart rate variability is assessed by determining the 'bandwidth'of the baseline
due to the opposing activity of the sympathetic and parasympathetic nervous systems …

The most significant problem impeding scientific progress in perinatal brain injury is the lack
of knowledge of the onset, nature, and timing of the insult in the antenatal and natal period …