Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …

Inosine is a dietary supplement that is widely used for managing numerous central
neurological disorders. Interestingly, recent experimental investigation of inosine revealed …

Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often
develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is …

Adenosine is an endogenous nucleoside that regulates many physiological and
pathological processes. It is derived from either the intracellular or extracellular …

Chronic pain (CP) is a prevalent problem, and more than half of patients with CP have sleep
disorders. CP comorbidity with sleep disorders imposes immense suffering and seriously …

Agonists of the Gi protein-coupled A3 adenosine receptor (A3AR) have shown important
pain-relieving properties in preclinical settings of several pain models. Active as a …

Chronic pain has a debilitating consequences on health and lifestyle. The currently
available analgesics are often ineffective and accompanied by undesirable adverse effects …

Injuries to the spinal cord result in permanent disabilities that limit daily life activities. The
main reasons for these poor outcomes are the limited regenerative capacity of central …

The specific adenosine A3 receptor (A3AR) agonist (CF101) has potential for inflammation
and pain in various disease, such as arthritis, cancer and neuropathic pain, while the role of …