[HTML][HTML] Metabolic-associated fatty liver disease and lipoprotein metabolism
J Heeren, L Scheja - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …
A researcher's guide to preclinical mouse NASH models
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
[HTML][HTML] Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases
Y Song, J Liu, K Zhao, L Gao, J Zhao - Cell metabolism, 2021 - cell.com
High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …
the past two decades, however, a number of studies have shown that excess cholesterol …
Mechanisms of NAFLD development and therapeutic strategies
There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD),
paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum …
paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum …
[HTML][HTML] Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Elevated liver de novo lipogenesis contributes to non-alcoholic steatohepatitis (NASH) and
can be inhibited by targeting acetyl-CoA carboxylase (ACC). However, hypertriglyceridemia …
can be inhibited by targeting acetyl-CoA carboxylase (ACC). However, hypertriglyceridemia …
Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of develo** hepatocellular carcinoma (HCC). Even after complete HCC …
are at a high risk of develo** hepatocellular carcinoma (HCC). Even after complete HCC …
[PDF][PDF] A systematic review of animal models of NAFLD finds high‐fat, high‐fructose diets most closely resemble human NAFLD
YR Im, H Hunter, D de Gracia Hahn, A Duret… - …, 2021 - Wiley Online Library
Background and Aims Animal models of human disease are a key component of
translational hepatology research, yet there is no consensus on which model is optimal for …
translational hepatology research, yet there is no consensus on which model is optimal for …
[HTML][HTML] The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease
K Sawada, H Chung, S Softic, ME Moreno-Fernandez… - Cell Metabolism, 2023 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease
Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …
Fructose and hepatic insulin resistance
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk
factor for development of obesity and its complications, such as fatty liver disease and …
factor for development of obesity and its complications, such as fatty liver disease and …