Foetal development and infancy are life stages that are characterised by rapid growth,
development and maturation of organs and systems. Variation in the quality or quantity of …

An adverse foetal environment is associated with increased risk of cardiovascular,
metabolic, neuroendocrine and psychological disorders in adulthood. Exposure to stress …

1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they
permanently change their structure and metabolism. 2. These'programmed'changes may be …

The “fetal” or “early” origins of adult disease hypothesis was originally put forward by David
Barker and colleagues and stated that environmental factors, particularly nutrition, act in …

Many human fetuses have to adapt to a limited supply of nutrients. In doing so they
permanently change their structure and metabolism. These programmed changes may be …

Epidemiological evidence suggests that an adverse fetal environment permanently
programs physiology, leading to increased risks of cardiovascular, metabolic, and …

The placenta is the primary interface between the fetus and mother and plays an important
role in maintaining fetal development and growth by facilitating the transfer of substrates and …

Low birth weight, thinness and short body length at birth are now known to be associated
with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult …

The association between low birth weight and raised blood pressure has been extensively
replicated. Little is known about the way childhood growth modifies the effects of low birth …

The fetal origins hypothesis proposes that adult cardiovascular and metabolic disease
originate through developmental plasticity and fetal adaptations arising from failure of the …