Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Exosomes, nanoscale extracellular vesicles functioning as cell-to-cell communicators, are
an emerging promising therapeutic in the field of bone tissue engineering. Here, we report …

Bone defects caused by trauma, severe infection, tumor resection and skeletal abnormalities
are common osteoporotic conditions and major challenges in orthopedic surgery, and there …

Background Recently, accumulating evidence has shown that exosomes, the naturally
secreted nanocarriers of cells, can exert therapeutic effects in various disease models in the …

Introduction 'Patient-specific'induced pluripotent stem cells (iPSCs) are attractive because
they can generate abundant cells without the risk of immune rejection for cell therapy …

Background Human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-
MSCs) have emerged as a promising alternative for stem cell transplantation therapy …

Background: Local ischemia is the main pathological performance in osteonecrosis of the
femoral head (ONFH). There is currently no effective therapy to promote angiogenesis in the …