The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Introduction Establishing whether specific structural and functional configurations of a
human gut microbiota are causally related to a given physiologic or disease phenotype is …

Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …

Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …

Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …

Fatty acids (FA) and FA-derived metabolites have long been implicated in the development
of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics …

Nearly unlimited supplies of energy-dense foods and technologies that encourage
sedentary behaviour have introduced a new threat to the survival of our species: obesity and …

High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a
major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction …

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder which is
associated with accumulation of fats in the liver. It causes a wide variety of pathological …