Animal models for COVID-19

C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …

[HTML][HTML] A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice

SR Leist, KH Dinnon, A Schäfer, VT Long**, K Okuda… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …

Musculoskeletal consequences of COVID-19

NP Disser, AJ De Micheli, MM Schonk, MA Konnaris… - JBJS, 2020 - journals.lww.com
Abstract Coronavirus disease 2019 (COVID-19) is an emerging pandemic disease caused
by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the …

[HTML][HTML] Masks do more than protect others during COVID-19: reducing the inoculum of SARS-CoV-2 to protect the wearer

M Gandhi, C Beyrer, E Goosby - Journal of general internal medicine, 2020 - Springer
Although the benefit of population-level public facial masking to protect others during the
COVID-19 pandemic has received a great deal of attention, we discuss for one of the first …

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

R Channappanavar, S Perlman - Seminars in immunopathology, 2017 - Springer
Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic
coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild …

Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis

LE Gralinski, TP Sheahan, TE Morrison, VD Menachery… - MBio, 2018 - journals.asm.org
Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are
observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) …

SARS and MERS: recent insights into emerging coronaviruses

E De Wit, N Van Doremalen, D Falzarano… - Nature reviews …, 2016 - nature.com
Abstract The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in
2012 marked the second introduction of a highly pathogenic coronavirus into the human …

Host factors in coronavirus replication

AH De Wilde, EJ Snijder, M Kikkert… - Roles of host gene and …, 2017 - Springer
Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …

The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity

IG Ovsyannikova, IH Haralambieva… - Immunological …, 2020 - Wiley Online Library
This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …