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Tandem repeats lead to sequence assembly errors and impose multi-level challenges for genome and protein databases
The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …
A roadmap for understanding the evolutionary significance of structural genomic variation
Structural genomic variants (SVs) are ubiquitous and play a major role in adaptation and
speciation. Yet, comparative and population genomics have focused predominantly on gene …
speciation. Yet, comparative and population genomics have focused predominantly on gene …
SyRI: finding genomic rearrangements and local sequence differences from whole-genome assemblies
Genomic differences range from single nucleotide differences to complex structural
variations. Current methods typically annotate sequence differences ranging from SNPs to …
variations. Current methods typically annotate sequence differences ranging from SNPs to …
A high-quality apple genome assembly reveals the association of a retrotransposon and red fruit colour
L Zhang, J Hu, X Han, J Li, Y Gao, CM Richards… - Nature …, 2019 - nature.com
A complete and accurate genome sequence provides a fundamental tool for functional
genomics and DNA-informed breeding. Here, we assemble a high-quality genome (contig …
genomics and DNA-informed breeding. Here, we assemble a high-quality genome (contig …
XSEDE: accelerating scientific discovery
Computing in science and engineering is now ubiquitous: digital technologies underpin,
accelerate, and enable new, even transformational, research in all domains. Access to an …
accelerate, and enable new, even transformational, research in all domains. Access to an …
Pangenome graphs
Low-cost whole-genome assembly has enabled the collection of haplotype-resolved
pangenomes for numerous organisms. In turn, this technological change is encouraging the …
pangenomes for numerous organisms. In turn, this technological change is encouraging the …
[HTML][HTML] Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila
High quality reference genomes are crucial to understanding genome function, structure and
evolution. The availability of reference genomes has allowed us to start inferring the role of …
evolution. The availability of reference genomes has allowed us to start inferring the role of …
[PDF][PDF] Going beyond SNPs: The role of structural genomic variants in adaptive evolution and species diversification.
Although single‐nucleotide polymorphism (SNPs) were initially thought to make‐up the
majority of selectable variation (Morin, Luikart, & Wayne, 2004; Sachidanandam et al …
majority of selectable variation (Morin, Luikart, & Wayne, 2004; Sachidanandam et al …
Discovery and population genomics of structural variation in a songbird genus
Structural variation (SV) constitutes an important type of genetic mutations providing the raw
material for evolution. Here, we uncover the genome-wide spectrum of intra-and interspecific …
material for evolution. Here, we uncover the genome-wide spectrum of intra-and interspecific …
Demography and its effects on genomic variation in crop domestication
Over two thousand plant species have been modified morphologically through cultivation
and human use. Here, we review three aspects of crop domestication that are currently …
and human use. Here, we review three aspects of crop domestication that are currently …