Globally, depression is a leading cause of disability and has remained so for decades.
Antidepressant medications have suboptimal outcomes and are too frequently associated …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Background: It is necessary to seek alternative therapies for depression, because side
effects of medications lead to poor adherence and some patients do not achieve a clinical …

Background Low levels of physical activity (PA) and sedentary behavior (SB) are
independent risk factors for cardiovascular disease and premature mortality in people with …

We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical
exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms …

Major depression shortens life while the effectiveness of frontline treatments remains
modest. Exercise has been shown to be effective both in reducing mortality and in treating …

Objective Exercise has established efficacy in improving depressive symptoms. Dropouts
from randomized controlled trials (RCT's) pose a threat to the validity of this evidence base …

Background The efficacy of exercise interventions in the treatment of mental health disorders
is well known, but research is lacking on the most efficient exercise type for specific mental …

Background Few studies have directly compared the effects of different exercise therapies
on clinical depression in older adults. Thus, we conducted a systematic review and network …

An update is available for this article. Background: Primary care patients and clinicians may
prefer alternative options to second-generation antidepressants for major depressive …