Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with
oncogenesis and tumour progression. Following transformation, the modulation of enzymes …

To become resistant, cancer cells need to activate and maintain molecular defense
mechanisms that depend on an energy trade-off between resistance and essential functions …

An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Biochemical analyses reveal that plasma contains over 600 structural forms of lipid
molecules. This review summarizes known correlations between levels of lipid moieties and …

Following the impetus of early clinical and experimental investigations, in vivo and in vitro
MRS studies of tumours pointed in the eighties to the possible significance of signals arising …

Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …

Choline is a vitamin-like nutrient that is taken up via specific transporters and metabolized by
choline kinase, which converts it to phosphocholine needed for de novo synthesis of …

All cancers tested so far display abnormal choline and ethanolamine phospholipid
metabolism, which has been detected with numerous magnetic resonance spectroscopy …

Abstract Infection with Human papillomaviruses (HPVs) leads to the development of a wide-
range of cancers, accounting for 5% of all human cancers. A prominent example is cervical …

Background & Aims Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the
predominant pediatric liver cancer, with limited therapeutic options for patients with …