WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for
Alzheimer's disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal …

Animal models of epilepsy are of great importance in epileptology. They are used to study
the mechanisms of epileptogenesis, and search for new genes and regulatory pathways …

Developmental and epileptic encephalopathies (DEE) are a group of disorders associated
with intractable seizures, brain development, and functional abnormalities, and in some …

The common marmoset (Callithrix jacchus) has emerged as a valuable nonhuman primate
model in biomedical research with the recent release of high-quality reference genome …

Objective WWOX is an autosomal recessive cause of early infantile developmental and
epileptic encephalopathy (WWOX‐DEE), also known as WOREE (WWOX‐related epileptic …

WWOX gene loss-of-function (LoF) has been associated with neuropathologies resulting in
developmental, epileptic, and ataxic phenotypes of varying severity based on the level of …

When WWOX is downregulated in middle age, aggregation of a protein cascade, including
TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more …

Epilepsy is a common neurological disorder that affects 1% of the global population. The
neonatal period constitutes the highest incidence of seizures. Despite the continual …

WW domain‐containing oxidoreductase (WWOX) is an emerging neural gene‐regulating
homeostasis of the central nervous system. Germline biallelic mutations in WWOX cause …

The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a
putative tumor suppressor spanning the common fragile site FRA16D, but as time has …