Tuberculosis drug discovery: challenges and new horizons
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Drug-resistant tuberculosis: a persistent global health concern
Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …
[BOOK][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …
Indole propionic acid, an unusual antibiotic produced by the gut microbiota, with anti-inflammatory and antioxidant properties
Most antibiotics are produced by soil microbes and typically interfere with macromolecular
synthesis processes as their antibacterial mechanism of action. These natural products are …
synthesis processes as their antibacterial mechanism of action. These natural products are …
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population
of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments …
of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments …
A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis
Long diagnostic wait times hinder international efforts to address antibiotic resistance in M.
tuberculosis. Pathogen whole genome sequencing, coupled with statistical and machine …
tuberculosis. Pathogen whole genome sequencing, coupled with statistical and machine …
The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis
BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
Pharmacological and molecular mechanisms behind the sterilizing activity of pyrazinamide
Inclusion of pyrazinamide (PZA) in the tuberculosis (TB) drug regimen during the 1970s
enabled a reduction in treatment duration from 12 to 6 months. PZA has this remarkable …
enabled a reduction in treatment duration from 12 to 6 months. PZA has this remarkable …
GenTB: A user-friendly genome-based predictor for tuberculosis resistance powered by machine learning
Abstract Background Multidrug-resistant Mycobacterium tuberculosis (Mtb) is a significant
global public health threat. Genotypic resistance prediction from Mtb DNA sequences offers …
global public health threat. Genotypic resistance prediction from Mtb DNA sequences offers …
Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis
Development of novel anti-tuberculosis combination regimens that increase efficacy and
reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs …
reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs …