Fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) are commonly
used as MRI biomarkers of white matter microstructure in diffusion MRI studies of …

Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes.
Processes including myelination and synaptogenesis occur rapidly across the first 2–3 years …

Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Magnetic resonance (MR) is a powerful technique for noninvasively probing molecular
species in vivo but suffers from low signal sensitivity. Saturation transfer (ST) MRI …

Magnetization transfer contrast has yielded insight into brain tissue microstructure changes
across the lifespan and in a range of disorders. This progress has been aided by the …

The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured
by myelin‐insulating sheaths surrounding axons. Human cognition, sensation, and motor …

Abstract Inhomogeneous Magnetization Transfer (ihMT) is a development from the MT MRI
technique. IhMT can be considered as a dipolar order relaxation time (T 1D) weighted …

White matter development has been well described using diffusion tensor imaging (DTI), but
the microstructural processes driving development remain unclear due to methodological …